Rachel, a perky housewife, has it all - a home, a husband, and children. However, on the night before Christmas, her husband hires a hit man and she loses it all. As a result, Rachel flees dressed in nothing more than her flannel nightgown. She embarks on an adventure that takes her through all 50 states as she searches for security and also sanity. Rachel not only meets a series of increasingly surreal adventures on her journey, but she also encounters a bizarre cast of characters; several of which include a suspicious social worker, his paraplegic deaf mute wife, a game show host, an insomniac undergrad, a nun, and a shrink who insists that Rachel's nightmarish life is actually one outrageous dream.